Biological Evaluation




Biological Evaluation

Shared Resources Director: Bennett Elzey, Ph.D.
E-mail: belzey@purdue.edu 
Phone: (317) 278- 3449
Building/Room: HANS
 
In cancer biology, mouse models continue to play significant roles in studies of tumor invasion, metastasis and malignant transformation, as well as in studies examining responses to therapy. Key advancements have emerged in the development of animal models for cancer biology, including the advent of orthotopic models for metastasis, transgenic animals that have developmental pathways to tumorigenesis, and state-of-the-art immunocompromised strains.  Transplanted human xenografts remain a primary tool for molecular discovery and evaluation.  Despite their flaws and shortcomings, xenograft mouse models have played a significant role in cancer drug development in the past three decades, and mouse models will continue to be a foundation in the war against cancer. At the Purdue University Center for Cancer Research (PCCR) where a vast pipeline of potential new agents for diagnosing and treating cancer are emerging, researchers need a productive and established facility for in vivo testing which can navigate the arena of murine cancer models.  The mission of the Biological Evaluation Shared Resource (BE-SR) is to provide expert guidance to investigators in grant preparation, model selection and experimental design, and to perform toxicity testing and proof-of-concept efficacy studies to advance their projects using in vivo testing.   
 
Services include:
Consultation, Grant Writing, HFA, LD50, MTD, PK, Efficacy and Animal Protocol Preparation

*NOTE: costs are approximate for a 20-mouse study

Service PCCR Rate
Consultation No Cost
Grant Writing No Cost
HFA  $  1,600.00
LD50  $  1,100.00
MTD  $  1,100.00
PK  $  1,400.00
Efficacy Study  $  2,000.00
Animal Protocol Preparation No Cost


Biological Evaluation Facility, HANS