Drug Delivery and Cancer:
Challenges and New Directions for Cancer Therapy
October 10-11, 2011
Purdue University, Pfendler Hall (PFEN) 241
West Lafayette, Indiana, USA
The objective of this workshop is different than most: rather than discuss recent successes in drug delivery, we wish to focus on unsolved problems that impede progress, and to determine why so many promising leads have failed to produce major improvements in cancer chemotherapy.
An international panel of experts will present their perspectives on practical problems in drug delivery. By holding an honest and introspective discourse on the present limitations in drug delivery research, we can better define the factors that have kept promising drug delivery systems from achieving their full potential.
Monday, October 10, 2011 [Pfendler Hall room 241]
8:00 am: Registration and Continental Breakfast
8:30 am: Introductory remarks: Dr. Alex Wei, Purdue University
I. Challenges for in vivo Delivery
8:40–9:10 am: “Barriers to Overcome for Targeted Drug Delivery to Tumors”: Dr. Kinam Park, Purdue University
9:20–9:50 am: “Challenges in Targeted Drug Delivery”: Dr. You Han Bae, University of Utah
10:00–10:30 am: “Macromolecular Therapeutics: EPR Effect and Beyond”: Dr. Hiroshi Maeda, Sojo University (Japan)
10:40–11:10 am: “Implantable Drug Delivery Systems and the Foreign Body Reaction”: Dr. James Anderson, Case Western Reserve University
11:20–11:50 pm: "Delivery of nanovectors in vivo by hitching a ride with the Immune System": Dr. Susan Clare, Indiana University Purdue University Indianapolis
12:00 pm-1:15 pm: Lunch
II. Challenges for Pharmacokinetic Models
1:15–1:45 pm: “Microfluidic Tumor Models”: Dr. Shuichi Takayama, University of Michigan
1:55–2:25 pm: "Tissue Barriers to Drug and Gene Delivery": Dr. Suzie Pun, University of Washington
2:35–3:05 pm: "Multi-Parameter Characterization of Targeted Drug Delivery Systems": Dr. Silvia Muro Galindo, University of Maryland
3:15–3:30 pm: Refreshment Break
3:30–4:00 pm: "The Challenges and Advantages for Moving from IV to SC delivery for Cancer Therapeutics": Dr. Ann Daugherty, Genentech Inc., San Francisco, CA
4:10–4:40 pm: “Challenges for Effective Nano-Theranostics”: Dr. Chun Li, MD Anderson Cancer Center
4:50–5:20 pm: "Targeted Nanoparticles: Chimera or Reality?": Dr. Sandy Florence, University of London
Tuesday, October 11, 2011 [Pfendler Hall room 241]
8:00 am: Continental Breakfast
III. Challenges for Formulations
8:30-9:00 am: “Solubilization Challenges in the Formulation of Anticancer Drugs”: Dr. Rodolfo Pinal, Purdue University
9:10-9:40 am: “Strategies to Enhance Targeting to and Intracellular Trafficking Outcomes within Epithelial-Derived Cancer Cells”: Dr. Randy Mrsny, University of Bath (UK)
9:50-10:20 am: “Combining Albumin-Binding Prodrugs with Other Anticancer Drugs, MDR Modulators and Enhancers of the EPR effect: Our in vitro and in vivo Experiences”: Dr. Felix Kratz, University of Freiburg (Germany)
10:30-11:00 am: “Receptor-Mediated Anticancer Drug Delivery Using Lipid Nanoparticles”: Dr. Yu-Kyoung Oh, Seoul National University, Korea
11:10-11:40 pm: "Preclinical Assessment of Cancer Nanomedicines Beyond Proof-of-Principle: Opportunities and Challenges": Dr. Anil Patri, National Cancer Institute, Washington DC
11:50 am: Lunch and open discussion with speaker panel [optional]
Registration is FREE of charge and includes breakfast and lunch on 10/10/11 and 10/11/11. The lunch/open discussion on 10/11 is optional so please indicate your participation when you register.
NOTE: Registration deadline is September 30, 2011.
We have reserved a block of rooms at the following hotels:
Hilton Garden Inn
356 East State Street
West Lafayette, Indiana, USA 47906
Room rate is $ 98.00 per night
Use code "DDMS" to reserve your room at this special rate.
Deadline for reservations is September 19, 2011
The Hilton will provide complimentary shuttle service to Purdue upon request.
Holiday Inn Lafayette City Centre
515 South Street
Lafayette, Indiana, USA 47901
Room rate is $ 97.00 per night
Use code "PCC" (Purdue Center for Cancer Research) to reserve your room at this special rate.
Deadline for reservations is September 19, 2011
The Holiday Inn will provide complimentary shuttle service to Purdue upon request.
Please contact the hotel directly to arrange your hotel accommodations.
Purdue University/West Lafayette is served by the Indianapolis International Airport (IND). Ground transportation from the Indianapolis Airport to Purdue University/West Lafayette is available through Lafayette Limo.
Flights can also be arranged through Chicago O'Hare International Airport (ORD). Ground transportation from Chicago O'Hare to Purdue University/West Lafayette is available through Express Air Coach.
MAPS AND DIRECTIONS:
The meeting will be held in room 241 of Pfendler Hall (715 West State Street on the corner of South University Drive) on the campus of Purdue University in West Lafayette, Indiana.
Parking is available at the Grant Street Parking Garage, (120 N. Grant Street) which is directly across from the Purdue Memorial Union, and approximately 4 blocks from Pfendler Hall. Parking passes will be provided to participants at their request during registration check-in.
Directions from Chicago and/or Indianapolis:
Exit I-65 at Exit 172 and proceed west (toward Lafayette) on State Road 26 (South Street). Proceed four miles to West Lafayette. (Be sure to follow the SR 26 signs carefully. At the intersection with Main Street, SR 26 will jog one block north and become Columbia Street.) When you cross the Wabash River you are in West Lafayette and are now on State Street. Proceed to the fourth traffic light and turn right on Grant Street. The Grant Street Parking Garage (PGG on campus map) will be ½ block on your right.
QUESTIONS? Contact Kim Crist at firstname.lastname@example.org.
This event is sponsored by the Purdue University Center for Cancer Research