March is Colorectal Cancer Awareness Month



 

What is colorectal cancer?

Colorectal cancer is cancer that starts in the colon or the rectum. These cancers can also be referred to separately as colon cancer or rectal cancer, depending on where they start. Colon cancer and rectal cancer have many features in common.  

In most people, colorectal cancers develop slowly over several years. Before a cancer develops, a growth of tissue or tumor usually begins as a non-cancerous polyp on the inner lining of the colon or rectum. A tumor is abnormal tissue and can be benign (not cancer) or malignant (cancer). A polyp is a benign, non-cancerous tumor. Some polyps can change into cancer but not all do. The chance of changing into a cancer depends upon the kind of polyp:

If cancer forms in a polyp, it can eventually begin to grow into the wall of the colon or rectum. When cancer cells are in the wall, they can then grow into blood vessels or lymph vessels. Lymph vessels are thin, tiny channels that carry away waste and fluid. They first drain into nearby lymph nodes, which are bean-shaped structures containing immune cells that help fight against infections. Once cancer cells spread into blood or lymph vessels, they can travel to nearby lymph nodes or to distant parts of the body, such as the liver. Spread to distant parts of the body is called metastasis
 

Types of cancer in the colon and rectum

Several types of cancer can start in the colon or rectum.

Adenocarcinomas: More than 95% of colorectal cancers are a type of cancer known as adenocarcinomas. These cancers start in cells that form glands that make mucus to lubricate the inside of the colon and rectum. When doctors talk about colorectal cancer, this is almost always what they are referring to. 



What are the risk factors of colorectal cancer?


Risk factors you cannot change

Age
Younger adults can develop colorectal cancer, but the chances increase markedly after age 50: More than 9 out of 10 people diagnosed with colorectal cancer are older than 50.

Personal history of colorectal polyps or colorectal cancer
If you have a history of adenomatous polyps (adenomas), you are at increased risk of developing colorectal cancer. This is especially true if the polyps are large or if there are many of them.

Personal history of inflammatory bowel disease
Inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, is a condition in which the colon is inflamed over a long period of time.

Family history of colorectal cancer
Most colorectal cancers occur in people without a family history of colorectal cancer. Still, as many as 1 in 5 people who develop colorectal cancer have other family members who have been affected by this disease.

People with a history of colorectal cancer or adenomatous polyps in one or more first-degree relatives (parents, siblings, or children) are at increased risk. The risk is about doubled in those with only one affected first-degree relative. It is even higher if that relative was diagnosed with cancer when they were young, or if more than one first-degree relative is affected.

Inherited syndromes
About 5% to 10% of people who develop colorectal cancer have inherited gene defects (mutations) that cause the disease. Often, these defects lead to cancer that occurs at a younger age than is common. Identifying families with these inherited syndromes is important because it lets doctors recommend specific steps, such as screening and other preventive measures when the person is younger.

Familial adenomatous polyposis (FAP): FAP is caused by changes (mutations) in the APC gene that a person inherits from his or her parents. About 1% of all colorectal cancers are due to FAP.

People with FAP typically develop hundreds or thousands of polyps in their colon and rectum, usually in their teens or early adulthood. Cancer usually develops in 1 or more of these polyps as early as age 20. By age 40, almost all people with this disorder will have developed cancer if preventive surgery (removing the colon) is not done.
Gardner syndrome is a type of FAP that also has benign (non-cancerous) tumors of the skin, soft connective tissue, and bones.

Hereditary non-polyposis colon cancer (HNPCC):HNPCC, also known as Lynch syndrome, accounts for about 3% to 5% of all colorectal cancers. HNPCC can be caused by inherited changes in a number of different genes that normally help repair DNA damage.

Turcot syndrome:This is a rare inherited condition in which people are at increased risk of adenomatous polyps and colorectal cancer, as well as brain tumors.

Peutz-Jeghers syndrome:People with this rare inherited condition tend to have freckles around the mouth (and sometimes on the hands and feet) and a special type of polyp in their digestive tracts (called hamartomas). They are at greatly increased risk for colorectal cancer, as well as several other cancers, which usually appear at a younger than normal age. This syndrome is caused by mutations in the gene STK1.

MUTYH-associated polyposis: People with this syndrome develop colon polyps which will become cancerous if the colon is not removed. They also have an increased risk of cancers of the small intestine skin, ovary, and bladder. This syndrome is caused by mutations in the gene MUTYH.

Racial and ethnic background
African Americans have the highest colorectal cancer incidence and mortality rates of all racial groups in the United States. The reasons for this are not yet understood.
Jews of Eastern European descent (Ashkenazi Jews) have one of the highest colorectal cancer risks of any ethnic group in the world. Several gene mutations leading to an increased risk of colorectal cancer have been found in this group. The most common of these DNA changes, called the I1307K APC mutation, is present in about 6% of American Jews.


Lifestyle-related factors

Several lifestyle-related factors have been linked to colorectal cancer. In fact, the links between diet, weight, and exercise and colorectal cancer risk are some of the strongest for any type of cancer.

Certain types of diets
A diet that is high in red meats (beef, lamb, or liver) and processed meats (hot dogs and some luncheon meats) can increase colorectal cancer risk. Cooking meats at very high temperatures (frying, broiling, or grilling) creates chemicals that might increase cancer risk, but it's not clear how much this might contribute to an increase in colorectal cancer risk. Diets high in vegetables, fruits, and whole grains have been linked with a decreased risk of colorectal cancer, but fiber supplements do not seem to help. It's not clear if other dietary components (for example, certain types of fats) affect colorectal cancer risk.

Physical inactivity
If you are not physically active, you have a greater chance of developing colorectal cancer. Increasing activity may help reduce your risk.

Obesity
If you are very overweight, your risk of developing and dying from colorectal cancer is increased. Obesity raises the risk of colon cancer in both men and women, but the link seems to be stronger in men.

Smoking
Long-term smokers are more likely than non-smokers to develop and die from colorectal cancer. Smoking is a well-known cause of lung cancer, but some of the cancer-causing substances in smoke dissolve into saliva and if swallowed, can cause digestive system cancers like colorectal cancer.

Heavy alcohol use
Colorectal cancer has been linked to the heavy use of alcohol. At least some of this may be due to the fact that heavy alcohol users tend to have low levels of folic acid in the body. Still, alcohol use should be limited to no more than 2 drinks a day for men and 1 drink a day for women.

Type 2 diabetes
People with type 2 (usually non-insulin dependent) diabetes have an increased risk of developing colorectal cancer. Both type 2 diabetes and colorectal cancer share some of the same risk factors (such as excess weight). But even after taking these into account, people with type 2 diabetes still have an increased risk. They also tend to have a less favorable prognosis (outlook) after diagnosis. 


How is colorectal cancer diagnosed?

Screening is the process of looking for cancer in people who have no symptoms of the disease. Several different tests can be used to screen for colorectal cancers. These tests can be divided into 2 broad groups:
 

  1. Tests that can find both colorectal polyps and cancer: These tests look at the structure of the colon itself to find any abnormal areas. This is done either with a scope inserted into the rectum or with special imaging (x-ray) tests. Polyps found before they become cancerous can be removed, so these tests may prevent colorectal cancer. This is why these tests are preferred if they are available and you are willing to have them.
     
  2. Tests that mainly find cancer: These test the stool (feces) for signs that cancer may be present. These tests are less invasive and easier to have done, but they are less likely to detect polyps.

These tests as well as others can also be used when people have symptoms of colorectal cancer and other digestive diseases.
 

Tests that can find both colorectal polyps and cancer

Flexible sigmoidoscopy

During this test, the doctor looks at part of the colon and rectum with a sigmoidoscope -- a flexible, lighted tube about the thickness of a finger with a small video camera on the end. It is inserted through the rectum and into the lower part of the colon. Images from the scope are viewed on a display monitor.

Colonoscopy

For this test, the doctor looks at the entire length of the colon and rectum with a colonoscope, which is basically a longer version of a sigmoidoscope. It is inserted through the rectum into the colon. The colonoscope has a video camera on the end that is connected to a display monitor so the doctor can see and closely examine the inside of the colon. Special instruments can be passed through the colonoscope to remove (biopsy) any suspicious looking areas such as polyps, if needed.
 

Double-contrast barium enema

The double-contrast barium enema (DCBE) is also called an air-contrast barium enema or abarium enema with air contrast. It may also be referred to as a lower GI series. It is basically a type of x-ray test. Barium sulfate, which is a chalky liquid, and air are used to outline the inner part of the colon and rectum to look for abnormal areas on x-rays. If suspicious areas are seen on this test, a colonoscopy will be needed to explore them further.

CT colonography (virtual colonoscopy)

This test is an advanced type of computed tomography (CT or CAT) scan of the colon and rectum. A CT scan is an x-ray test that produces detailed cross-sectional images of your body. Instead of taking one picture, like a regular x-ray, a CT scanner takes many pictures as it rotates around you while you lie on a table. A computer then combines these pictures into images of slices of the part of your body being studied. For CT colonography, special computer programs create both 2-dimensional x-ray pictures and a 3-dimensional "fly-through" view of the inside of the colon and rectum, which allows the doctor to look for polyps or cancer.

This test may be especially useful for some people who can't have or don't want to have more invasive tests such as colonoscopy. It can be done fairly quickly and does not require sedation. But even though this test is not invasive like colonoscopy, it still requires the same type of bowel preparation and uses a tube placed in the rectum (similar to the tube used for barium enema) to fill the colon with air. Another possible drawback is that if polyps or other suspicious areas are seen on this test, a colonoscopy will still likely be needed to remove them or to explore them fully.


Tests that mainly find colorectal cancer

These tests examine the stool to look for signs of cancer. Most people find these tests to be easier because they are not invasive and can often be done at home. But they are not as good at detecting polyps as the tests described above, and a positive result on one of these screening tests will likely require a more invasive test such as colonoscopy.

Fecal occult blood test

The fecal occult blood test (FOBT) is used to find occult blood (blood that can't be seen with the naked eye) in feces. The idea behind this test is that blood vessels at the surface of larger colorectal polyps or cancers are often fragile and easily damaged by the passage of feces. The damaged vessels usually release a small amount of blood into the feces, but only rarely is there enough bleeding for blood to be visible in the stool.

Fecal immunochemical test

The fecal immunochemical test (FIT), also called an immunochemical fecal occult blood test (iFOBT), is a newer kind of test that also detects occult (hidden) blood in the stool. This test reacts to part of the human hemoglobin protein, which is found in red blood cells.
The FIT is done essentially the same way as the FOBT, but some people may find it easier to use because there are no drug or dietary restrictions (vitamins or foods do not affect the FIT) and sample collection may take less effort. This test is also less likely to react to bleeding from parts of the upper digestive tract, such as the stomach.


Stool DNA tests

Instead of looking for blood in the stool, these tests look for certain abnormal sections of DNA (genetic material) from cancer or polyp cells. Colorectal cancer cells often contain DNA mutations (changes) in certain genes. Cells from colorectal cancers or polyps with these mutations are often shed in the stool, where tests may be able to detect them.

This is a newer type of test, and the best length of time to go between tests is not yet clear. This test is also much more expensive than other forms of stool testing.  The stool DNA test is not invasive and doesn't require any special preparation. But like other stool tests, if the results are positive, a colonoscopy will need to be done.

People at average risk

The American Cancer Society believes that preventing colorectal cancer (and not just finding it early) should be a major reason for getting tested. Finding and removing polyps keeps some people from getting colorectal cancer. Tests that have the best chance of finding both polyps and cancer are preferred if these tests are available to you and you are willing to have them.

Beginning at age 50, both men and women at average risk for developing colorectal cancer should use one of the screening tests below:

Tests that find polyps and cancer

Tests that mainly find cancer

People at increased or high risk

If you are at an increased risk or high risk of colorectal cancer, you should begin colorectal cancer screening before age 50 and/or be screened more often. The following conditions place you at higher than average risk:


 

Source:  Visit the American Cancer Society for treatment options and additional information on colorectal cancer.


What we're doing at the Purdue University Center for Cancer Research

Purdue Cancer Care Engineering Project goal is to discover biomarkers in individual's blood and tissue that will predict susceptibility to colon cancer...

2012 Cancer Benefit Concert to benefit colon cancer research.