Alliance for Cancer Gene Therapy

ACGT is the only public charity in the nation exclusively funding cancer cell and gene therapy research. By supporting research in discovery and translational research, we stimulate both innovation and progress.

1. The Fund for Advancement awards up to million to Principal Investigators conducting translational research that will move cell and gene therapies from the laboratory towards clinical trials.

Description
The Investigators Award in Clinical Translation of Gene Therapy for Cancer distributes funds over 3-5 years, inclusive of a maximum of 10% indirect costs. Funds may be used at the recipient's discretion for salary, technical assistance, supplies, animals or capital equipment, but may not support staff not directly related to the project, e.g. secretaries or administrative assistants. Purchase of equipment is not allowed in the final year of the grant.

ACGT Research Objectives
A number of cell and gene therapy approaches for cancer have been shown to be efficacious and safe in laboratory animal models in the recent years, but their translation into clinical trials has been hindered by a lack of resources. Recognizing this critical need, ACGT is accepting grant applications to produce and release-testing of the clinical trial agents under cGMP, conduct the necessary pre-clinical pharmacological and toxicological studies in appropriate animal models, and/or conducting the clinical translational trials in patients in support of an Investigative New Drug (IND) application to the FDA. While the unambiguous demonstration of preclinical efficacy in cancer treatment by cell and gene therapy is a pre-requisite, entering into the clinical trial during the funding period is also a requirement. Applications that do not include this specific aim will be deemed unresponsive to the RFA.

Eligibility
Candidates must hold an MD, PhD, or equivalent degree and be a tenure-track or tenured faculty. The investigator must be conducting original research as an independent faculty member. ACGT has no citizenship restrictions; however, research supported by the award must be conducted at medical schools and research centers in the United States and Canada. Entering into clinical translation during the funding period is a requirement. Continued support is contingent upon submission and approval of a non-competitive renewal application each year.

2. The Fund for Discovery awards up to 0,000 to Young Investigators [tenure track assistant professors] conducting innovative exploratory research.

Description
The Young Investigators Award distributes funds over 3 years, inclusive of a maximum of 10% indirect costs. Funds may be used at the recipient's discretion for salary, technical assistance, supplies, animals or capital equipment, but may not support staff not directly related to the project, e.g. secretaries or administrative assistants. Purchase of equipment is not allowed in the third year of the grant. Continued support is contingent upon submission and approval of a non-competitive renewal application each year.

ACGT Research Objectives
The overall objectives of this grant are to advance cell and gene therapy into the causes, treatment and prevention of all types of cancer by promoting development of novel and innovative studies by young investigators. The emphasis of this initiative is to promote basic, and pre-clinical research approaches utilizing cells and genes as medicine. ACGT will direct its grants into areas of cell and gene therapy research that have demonstrated great promise. The six main areas of research ACGT will support are:
 


Eligibility
At the time of award activation, candidates must hold an MD, MPH, PhD, or equivalent degree and be a tenure-track Assistant Professor within five years of their initial appointment to this rank. The investigator must be conducting original research as an independent faculty member. ACGT has no citizenship restrictions; however, research supported by the award must be conducted at medical schools and research centers only in the United States and Canada.

 

2011 Young Investigator Award Research Grant Deadlines:

Grant Abstract Deadline:
September 1, 2011 at 4pm E.S.T.

Invitation to Submit Application:
September 12, 2011

Deadline for Completed Application:
October 13, 2011 at 4 pm E.S.T.

Download RFA (PDF)