Medicinal Chemistry

medicinal chemistry

This program is focused on central activities required for the development of small organic molecules as cancer chemotherapeutic agents. Members of this program use a wide variety of approaches, including chemical, biochemical, cellular, and animal methods to design and discover drugs. These approaches include (but are not limited to):

  • Natural Product-Based Drug Design and Discovery – Synthesis of anticancer natural products and analogs thereof and biological studies on their mechanism of action.
  • Biologically-Targeted Drug Design – Design, synthesis, and biological evaluation of synthetic compounds as potential inhibitors of anticancer enzyme targets, and antagonists of anticancer receptors.
  • Screening of Biological Targets for Drug Discovery – Development and utilization of methods, including systems biology methods, for the high-throughput evaluation of potential anticancer agents.
  • Preclinical Models for Drug Development – Evaluation of potential chemotherapeutic and chemopreventive agents in cellular and animal cancer models.

Specific examples of activities in this program include:

  • Development of new synthetic routes to natural products known to function as antitumor or chemopreventive agents.
  • Mechanistic evaluation of new anticancer natural products.
  • Design and synthesis of targeted protein kinase inhibitors.
  • Design and synthesis of inhibitors of post-translational modifications.
  • Design and synthesis of topoisomerase inhibitors.
  • Development of systems methods for discovery of novel potential anticancer targets.
  • Studies of potential chemotherapeutic agents in mouse xenograph and other animal models.

Program Members:

R. Timothy Bentley, Veterinary Clinical Sciences
Richard F. Borch, Medicinal Chemistry & Molecular Pharmacology
Michael Childress, Veterinary Clinical Sciences
David Colby, Medicinal Chemistry & Molecular Pharmacology
Mark S. Cushman, Medicinal Chemistry & Molecular Pharmacology
Mingji Dai, Organic Chemistry
 V. Jo Davisson, Medicinal Chemistry & Molecular Pharmacology
Emily Dykhuizen, Medicinal Chemistry & Molecular Pharmacology
Jennifer Freeman, Health Sciences
Philip L. Fuchs, Organic Chemistry
Arun K. Ghosh, Chemistry and Medicinal Chemistry & Molecular Pharmacology
Tony R. Hazbun, Medicinal Chemistry & Molecular Pharmacology
Qing Jiang, Nutrition Science
Deborah W. Knapp, Co-leader, Veterinary Clinical Sciences
Casey Krusemark, Medicinal Chemistry & Molecular Pharmacology
Markus Lill, Medicinal Chemistry & Molecular Pharmacology
Mark A. Lipton, Chemistry
Philip S. Low, Chemistry
Sulma I. Mohammed, Comparative Pathobiology
Laurie Parker, Medicinal Chemistry & Molecular Pharmacology
Jeannie Poulson, Veterinary Clinical Sciences
John J. Turek, Basic Medical Sciences
David J. Waters, Veterinary Clinical Sciences

Click here to view our entire membership list.