Suresh Mittal, Professor of Comparative Pathology
Overexpression of the receptor tyrosine kinase, EphA2, occurs in the majority of invasive breast cancers, and successful binding of its ligand Ephrin-A1 has been shown to restore normal cellular functions. In normal breast cells and other adult epithelial cells, EphA2 is expressed at considerably low levels and is associated with its ligand, whereas, in breast cancer cells EphA2 is overexpressed and its significant amounts are not associated with its ligand. Dr. Mittal is focusing on the fact that EphA2 provides a unique cancer cell target for breast cancer intervention by adenoviral vectors.
For more information on Dr. Mittal, visit his department website here.